R-410A, sold under the trademarked names AZ-20, EcoFluor R410, Forane 410A, Genetron R410A, Puron, and Suva 410A, is a zeotropic but near-azeotropic mixture of difluoromethane (CH₂F₂, called R-32) and pentafluoroethane (CHF₂CF₃, called R-125) that is used as a refrigerant in air conditioning and heat pump applications. R-410A cylinders were colored rose but are no longer specially color-coded, now bearing a standard light gray color.

On December 27, 2020, the United States Congress passed the American Innovation and Manufacturing (AIM) Act, which directs US Environmental Protection Agency (EPA) to phase down production and consumption of hydrofluorocarbons (HFCs). HFCs have a high global warming potential and contribute to climate change. Rules developed under the AIM Act require HFC production and consumption to be reduced by 85% from 2022 to 2036. R-410A will be restricted by this Act because it contains the HFC R-125. Other refrigerants (like R-32 and R-454B) will replace R-410A in most applications, just as R-410A replaced the earlier refrigerant, R-22.